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Biology of Ageing

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medical...
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UFMG

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Raphael N.
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documents in English
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48 slides
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  1. The life course approach to the understanding of aging
  2. The evolutionary biological theory of aging: A satisfactory explanation for why we age
  3. Classes of gene action that escape the force of natural selection
  4. Environmentally triggered diapause and caloric restriction
  5. Human progeroid mutations
  6. Conclusions
  7. Bibliography

It is useful to think of organisms as protein-synthesizing factories. If that factory is to function at very high levels of efficiency and stability for very long periods of time, the builder should start with an excellent set of blueprints (hence the importance of understanding the constitutional genomes of individual patients), hire engineers and supervisors to oversee its construction and maturation Ensure that the factory functions in a safe environment (hence the importance of protecting patients from teratogens, mutagens, carcinogens, and candidate "gerontogens," such as tobacco smoke), and, finally, initiate rigorous regimens of quality control throughout the life span of the factory (hence the importance of such biologic processes as DNA repair and the detection, reconstitution, and turnover of aberrant proteins).

[...] All patients are likely to have one or more such "private" modulations that can have an impact on patterns of aging. Moreover, all patients also are likely to carry a private array of suppressor mutations at other loci to postpone the age of phenotypic expression. Environmentally Triggered Diapause and Caloric Restriction Can Increase the Life Spans of Diverse Organisms Research has implicated a homologous pathway of neuroendocrine modulation of life span in diverse organisms. The most detailed understanding has come from mutational studies of C. [...]


[...] This class of gene action has received a great deal of recent attention in connection with evidence that levels of the tumor suppressor gene, p53, have been "fine-tuned" by evolution both to decrease the risk of cancer and to decrease the rate of aging. Classes of Gene Action that Escape the Force of Natural Selection In mouse models, putative excessive functioning of p53 protects against cancer but is associated with decreased life spans and conditions such as osteopenia, multiple organ atrophy, and poor wound healing. [...]


[...] is to function at very high levels of efficiency and stability for very long periods of time, the builder should start with an excellent set of blueprints (hence the importance of understanding the constitutional genomes of individual patients), hire engineers and supervisors to oversee its construction and maturation The Life Course Approach to the Understanding of Aging Ensure that the factory functions in a safe environment (hence the importance of protecting patients from teratogens, mutagens, carcinogens, and candidate "gerontogens," such as tobacco smoke), and, finally, initiate rigorous regimens of quality control throughout the life span of the factory (hence the importance of such biologic processes as DNA repair and the detection, reconstitution, and turnover of aberrant proteins). [...]

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