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Crohn’s Disease

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Michael G.
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  1. Introduction
  2. Ulcerative Colitis
  3. The use of PCE-SSO techniques in a study
  4. Two different types of Crohn's disease
  5. Non perforating Crohn's Disease
  6. Its association with enteric microorganisms
  7. Conclusion
  8. Sources

Crohn's Disease is a form of ileitis, or inflammation of the ileum, which is the terminal portion of the small intestine. It is characterized by abdominal pain, ulceration, and fibrous tissue buildup in the terminal portion of the ileum. This is a relatively new disease, with proper medical diagnoses dating back only to the 1960s. Although Crohn, Ginzberg, and Oppenheimer described it in 1932 as a chronic, low grade inflammation of the terminal ileum, in 1960 it was recognized that the same disorder affected the colon and had been confused with ulcerative colitis. So, Crohn's disease is newly recognized, with a defined clinical and pathological description dating back only to the 1960s (Chiodini, 1989).

[...] In one study, PCE-SSO techniques were used to molecularly type individual alleles of all DRB1, DRB3, DRB4, and DRB5 loci and to compare the frequence of the known alleles among ethnically matched populations consisting of 40 ulcerative colitis patients Crohn's disease patients, and 93 healthy controls. The diagnosis of ulcerative colitis and Crohn's disease was documents in 82 patients seen at the Center for the Study of Inflammatory Bowel Disease by endoscopic, histological, and clinical criteria. All patients were Caucasian. [...]


[...] Crohn's Disease Crohn's Disease is a form of ileitis, or inflammation of the ileum, which is the terminal portion of the small intestine. It is characterized by abdominal pain, ulceration, and fibrous tissue buildup in the terminal portion of the ileum. This is a relatively new disease, with proper medical diagnoses dating back only to the 1960s. Although Crohn, Ginzberg, and Oppenheimer described it in 1932 as a chronic, low grade inflammation of the terminal ileum, in 1960 it was recognized that the same disorder affected the colon and had been confused with ulcerative colitis. [...]

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