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Digestion in the third age: drug interactions, liver changes and pancreas

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  1. Introduction
  2. Poisoning by Drugs
  3. Medicinal Products in the Elderly
  4. Liver
  5. Hepatitis
  6. Conclusion

The drug poisoning can be confused with viral hepatitis, with biliary tract obstruction with cirrhosis and hepatoma. The liver can be attacked in various ways: necrosis, hepatitis nonspecific, chronic hepatitis, etc. In the process are involved biotransformation of chemicals and individual susceptibility to them.

Generally not the product that acts directly on the liver, but some of its toxic metabolites. It is difficult to characterize the relationship between the cause and the effect. The hepatotoxic agent may be intrinsic or idiosyncratic type. The intrinsic type hepatotoxin acts quickly (hours or days) and is independent of the body's susceptibility (trichloroethane, solvents with carbon tetrachloride, certain mushrooms and acetaminophen). In type idiosyncratic hepatotoxin acts length (months) and has mixed developments (halothane, isoniazid, phenytoin and Chlorpromazine).

[...] The manifestations of chronic hepatitis are very discrete and often patients are asymptomatic. The main symptom, when present, is fatigue. May occur insomnia and pain in the right upper quadrant. In advanced stages there may be nausea, loss of appetite and weight loss. Most of the time the diagnosis is made through routine blood tests. The elevation of transaminases is the main laboratory characteristic of chronic hepatitis. Bilirubin and proteins in general are normal. There is often thrombocytopenia when the disease is progressing to cirrhosis. [...]


[...] Reach of the population each year and can be acute or chronic. The viral infection is usually self-limiting: disappear spontaneously without causing liver damage. Sometimes, however, the infection becomes persistent generating a process that cronifica, progressing to chronic hepatitis. Some parasites can lead to situations similar to hepatitis (schistosomiasis, malaria and amebiasis). Viral hepatitis are at least five types: D and E. With the exception of Type B (DNA virus), all are RNA viruses. The type A is the most common form of cases, followed by B C and 15%. [...]


[...] Form B can develop bad when it reaches the elderly. The diagnosis should be considered a pre-icteric phase called accompanied by fatigue, nausea, loss of appetite and pain in the right upper quadrant, lasting 3-10 days. Some forms do not go beyond this stage presenting positive serology and increased enzymes. The icteric phase is characterized by the presence of jaundice and bilirubinuria, worsening fatigue and nausea. There may be itchy skin and pale stools. The enzymes and bilirubin are increased. [...]


[...] Digestion in the third age: drug interactions, liver changes and pancreas Poisoning by Drugs The drug poisoning can be confused with viral hepatitis, with biliary tract obstruction with cirrhosis and hepatoma. The liver can be attacked in various ways: necrosis, hepatitis nonspecific, chronic hepatitis, etc. In the process are involved biotransformation of chemicals and individual susceptibility to them. Generally not the product that acts directly on the liver, but some of its toxic metabolites. It is difficult to characterize the relationship between the cause and the effect. [...]

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