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Diabetes in humans

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In Western society where food is increasingly rich in fats and lipids, the proportion of diabetics (150 million Type II diabetics) is such that the WHO describes the disease as the first global non-contagious epidemic [5]. The three different types of diabetes (IDDM, NIDDM, and DN) are increasingly being studied, especially with the recent discovery of neonatal diabetes called diabetes III. The objective of this thesis is to conduct a parallel between genes and functions that can be altered in diabetic conditions, and present the mutations involved in the patho-physiology of these diseases. The development of gene therapy led to the identification and location of candidate genes to treat these diseases, by treating the underlying problem. To meet this goal we will first discuss the generalities of blood sugar regulation and the mechanisms involved in the secretion of insulin and the genetic diseases that result from a dysfunction of these mechanisms.

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