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Narcolepsy

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About the author

 
Level
General public
Study
medical...
School/University
Harvard

About the document

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Language
documents in English
Format
.ppt
Type
presentations
Pages
33 slides
Level
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  1. Description
  2. Epidemiology
  3. Risk factors
  4. Etiology
  5. Diagnosis
  6. Signs and symptoms
  7. Tests
  8. Differential diagnosis
  9. Treatment
  10. Medication (drugs)
  11. Conclusions

Disorder of unknown etiology characterized by excessive sleepiness typically associated with cataplexy and other REM sleep phenomena, such as sleep paralysis and hypnagogic hallucinations. Commonly misconceived as representing low intelligence and/or poor motivation. Syndrome frequently overlooked, with an average of 15 years of symptoms prior to diagnosis. Onset usually in teenage years.

[...] hallucinations. Commonly misconceived as representing low intelligence and/or poor motivation. Syndrome frequently overlooked, with an average of 15 years of symptoms prior to diagnosis. Onset usually in teenage years. EPIDEMIOLOGY Predominant age: Mean age at onset 18 years Predominant sex: Male = Female ALERT Pediatric Considerations Uncommon in childhood Prevalence One in 3,000 diagnosed RISK FACTORS Head trauma CNS infectious disease Anesthesia Family history Genetics Autosomal recessive Increased incidence in families with positive history Incidence in 1st-degree relative of index case is (vs general population) Biologic marker HLA-DR2 allele on short arm of chromosome 6 in 100% of white patients; 1/3 normal subjects are also positive. [...]


[...] Glass Layers NARCOLEPSY DESCRIPTION Disorder of unknown etiology characterized by excessive sleepiness typically associated with cataplexy and other REM sleep phenomena, such as sleep paralysis and hypnagogic hallucinations. Commonly misconceived as representing low intelligence and/or poor motivation. Syndrome frequently overlooked, with an average of 15 years of symptoms prior to diagnosis. Onset usually in teenage years. EPIDEMIOLOGY Predominant age: Mean age at onset 18 years Predominant sex: Male = Female ALERT Pediatric Considerations Uncommon in childhood Prevalence One in 3,000 diagnosed RISK FACTORS Head trauma CNS infectious disease Anesthesia Family history Genetics Autosomal recessive Increased incidence in families with positive history Incidence in 1st-degree relative of index case is (vs general population) Biologic marker HLA-DR2 allele on short arm of chromosome 6 in 100% of white patients; 1/3 normal subjects are also positive. [...]

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