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Are bio active-rich fractions functionally richer?

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  1. Background
  2. Methodology for selection of studies
  3. Tocotrienol-rich fraction (TRF)
  4. Thymoquinone-rich fraction
  5. Oryzanol-rich fraction
  6. Other bioactive-rich fractions
  7. Discussion

Plant bioresources are relied upon as natural, inexpensive, and sustainable remedies for the management of several chronic diseases worldwide. Plants have historically been consumed for medicinal purposes based on traditional belief, but this trend is currently changing. The growing interest in the medicinal properties of plant bioresources stems from concerns of side effects and other adverse effects caused by synthetic drugs. This interest has yielded a better understanding of the roles of plant bioactive compounds in health promotion and disease prevention, including the underlying mechanisms involved in such functional effects.

[...] (LDL oxidation is not significantly different between low and high PUFA group). In HUVEC mM TRF treatment decreased TBARS by 73% compared with 50% by same concentration of a-tocopherol. Arachidonic acid-induced oxidative stress (conjugated dienes) was reduced to a similar level by 10 mM TRF or 25 mM a-tocopherol. TRF is a more potent antioxidant than a-tocopherol (in vitro) TRF and a-tocopherol were metabolized differently. Tocopherol was the major component detected in plasma in both cases, and it peaked at 6 h ( 13.46 1.68 mg/mL) and at 8 h ( 24.3 5.22 mg/mL) following TRF and a-tocopherol supplementation, respectively. [...]


[...] DOI: 10.3109 / Bioactive-rich fractions? 5 Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Kungliga Tekniska Hogskolan on 03/06/15 For personal use only M. U. Imam et al. Through in vitro experimentation, Al-Naqeeb and Ismail (2009) have demonstrated the effects of 2 ppm TQ against 80 ppm of a thymoquinone-rich fraction (TQRF containing 2 ppm TQ) on the expression of cholesterol-related genes (APO A1 and APO B100) in HEPG2 cells. The results indicated that the TQRF is able to favorably regulate cholesterol metabolism through upregulation of the APO A1 gene and downregulation of the APO B100 gene to a significantly greater degree than the same concentration of TQ present in the TQRF when used alone. [...]


[...] (2003). Palm-tocotrienol rich fraction (TRF) is a more effective inhibitor of LDL oxidation and endothelial cell lipid peroxidation than a-tocopherol in vitro. Food Res Int 405?13. Nafeeza Fauzee Kamsiah Gapor M. (2002). Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats. Asia Pacific J Clin Nutr 309?13. s Nergiz Otle¸ S. (1993). Chemical composition of Nigella sativa L. seeds. Food Chem 259?61. Ng Ko H-J. [...]


[...] (2005). Policosanol contents and composition of wheat varieties. J Agric Food Chem 5583?6. Ismail Al-Naqeeb Mamat WA, Ahmad Z. (2010b). Gammaoryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver. Nutr Metab 1?13. Ismail Al-Naqeep Chan KW. (2010a). Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med 664?72. Iwu MM. (2014). [...]


[...] In addition, both kaempferol and KGRF were reported to be effective at reducing inflammation and pain, although no differences were observed in their efficacies (Parveen et al., 2007). Discussion A limited number of bioactive compounds (Figure have been compared with their rich fractions, and such Bioactive-rich fractions? Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Kungliga Tekniska Hogskolan on 03/06/15 For personal use only. DOI: 10.3109 / Figure 1. Structures of bioactives (Chemspider, 2014). comparative studies (Table have mainly focused on oxidative stress, lipid peroxidation, antioxidants, inflammation, and cholesterol metabolism. [...]

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