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Neuropathic pain and its therapeutic approach

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  1. Introduction
  2. Mechanisms of pain
  3. Clinical features
  4. Diagnosis
  5. Treatment
  6. Specific therapies
  7. Stimulation of afferent fibers
  8. Topical treatment
  9. Surgery
  10. Bibliography

The study and treatment of peripheral neuropathies and neuralgia has become an important field of research. The pain associated with these pathological conditions has not yet been fully understood and still have not received the due interest in the common neurological tests. The pain caused by peripheral neuropathy or neuralgia, sometimes sporadic or chronic, may be resistant to treatment. However, a treatment regimen well-adjusted and applied to a unit of pain therapy, offers the best guarantees of a successful outcome, compared to other specialized approaches.Have been proposed different terms to define this type of pain linked to changes in the neurological functions, but what is now the preferred term, precisely, of neuropathic pain which only indicates its origin from functional abnormality of the nervous system.

[...] Effective therapy in the treatment of atypical facial neuralgia, and in some pain from neuropathy of the face was found to block the ganglion sfenopalatino. The block can be performed twice a week and does not need special equipment and brilliance of the amplifier. You run through Transnasal and in outpatient settings as low-toxic and not an invasive technique. The classic technique provides the direct application of lidocaine or drip directly targeted at the end of the middle turbinate and the upper near the foramen sfenopalatino with the patient supine, the neck slightly hyperesthesia. [...]


[...] The tocainide, other oral antiarrhythmic, appears to be useful in the treatment of certain neuralgias (400 mg orally three times a day) and mexiletine has proved effective in cases of neuropathy secondary to diabetes mellitus (200 mg orally three times daily The introduction in the treatment of neuropathic pain of gabapentin to medprotina, vigabatrin and lamotrigine is opening new therapeutic opportunities, especially as regards their association with pure analgesics. Between these and in this specific area, is producing a good effect on the tramadol. [...]


[...] With regard to a variety Polyneuropathies are staggering and are characterized by, selective and non-fiber: Type of loss fiber neuropathy Selective loss of large fibers from isoniazid From pellagra Selective loss of small fiber Fabry Disease Dominant sensory Diabetic Amiloidosica Non-selective loss Spirits Mielomatosa Perita unknown Guillain-Barre From Beri-Beri Arsenic By chloramphenicol By organophosphates By thallium Mechanisms of pain You know that the impulses that originate from primary afferent nociceptive fibers causes the appearance of pain depending on the number and frequency with which they reach the central nervous system. [...]

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