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The effect of surface functionalisation of zinc doped silica nanoparticles on cellular uptake

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  1. Nanoparticles in cancer treatment applications
  2. SiO2 (silica) nanoparticles and ZnO (zinc oxide) nanoparticles
  3. Properties and Mechanisms of Zinc and its Use in treatment of Cancer
  4. Cellular Uptake of Nanoparticles
  5. Importance of surface modification of nanoparticles on cellular uptake
  6. Liposome (Giant Unilamellar Vesicles) synthesis
  7. Experimental techniques to be used in this project
  8. Summary of literature review

Nanoparticles are described as particles that have less than 100 nanometre (nm) in a dimension (Khan and Arif, 2012, p. 85). Zinc (Zn) is one of the elements that has been known for its anti-cancer properties (Kim et al., 2013). On the other hand, silica nanoparticle (SiO2 NP) is one of the nanomaterial with a huge application particularly when it comes to the project of Nanomedicine (Sahu and Casciano, 2009, p. 125). As such, this project aims to investigate how the functionalizing of SiO2 NPs doped with Zn could affect its cellular uptake.
To learn more about the research topic, this project aims to see how the surface charge of the SiO2 NPs doped with Zn has an effect on cellular uptake. This project will also seek to determine whether or not surface functionalisation of SiO2 NPs doped with Zn could create significant changes within the cellular uptake. In the process of conducting a systematic literature review, it is possible for the reader to gain more insight on what has already been known and unknown when it comes to the possible effects of surface functionalisation of Zn SiO2 NPs doped with Zn on the cellular uptake and its potential for cancer therapy.

[...] American Physical Society, Joint Fall 2010 Meeting of the Texas Sections of the APS, AAPT, Zone 13 of SPS and the National Society of Hispanic Physicists. Bhattacharjee, S. et al Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells. Particle and Fibre Toxicology, pp. 25. Doi: 10.1186 /1743-8977-7-25. Boehm, T. et al Zinc-binding of endostatin is essential for its antiangiogenic activity. Biochemical and Biophysical Research Communications, pp. 252(1), pp. 190-194. Bogush, G., Tracy, M. & Zukoski, C Preparation of monodisperse silica particles: Control of size and mass fraction. Journal of Non- Crystalline Solids, 104(1), pp. 95-106. [...]

[...] Klingshirn, C., Waag, A., Hoffmann, A. & Geurts, J Zinc Oxide: From Fundamental Properties towards Novel Applications. London: Springer- Verlag. Lee, D. et al Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. Journal of the National Cancer Institute, pp. pp. 403-407. Lin, J. & Alexander-Katz, A Cell membranes open "doors" for cationic nanoparticles/biomolecules: insights into uptake kinetics. ACS Nano, pp. 10799- 10808. Lina, R. et al Property study of a new silica nanoparticle delivery system of hydrophobic phthalocyanine using spectroscopic method. [...]

[...] et al Cytotoxicity of ZnO Nanoparticles Can Be Tailored by Modifying Their Surface Structure: A Green Chemistry Approach for Safer Nanomaterials. ACS Sustainable Chemistry & Engineering, pp. pp. 1666?1673. Ramasamy, M., Das, M., A. S. & Yi, D Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells. International Journal of Nanomedicine, pp pp. 3707-3718. Sahu, S. & Casciano, D Nanotoxicity: From In Vivo and In Vitro Models to Health Risks. West Sussex: John Wiley & Sons. p Shah, M. [...]

[...] 28(35), pp. 12831- 12837. Zou, H., Wu, S. & Shen, J Polymer/Silica Nanocomposites: Preparation, Characterization, Properties, and Applications. Chemical Reviews, pp. 108(9), pp. 3893- 39573. [...]

[...] (See Figure 4 Structure of ZnO below) Figure Structure of ZnO (Jagadish and Pearton p. Note: White represents ?O' whereas black represents Zinc intercellular levels show a strong correlation that is inverse to the malignancy and growth of prostate cancer. Essentially, studies about Zn supplementation in prostate cancer in particular have hardly accounted for the bioavailability of Zn (Shah, Christopher, Nathan, Mary, Jamaluddin, Kelin, Baldassare, 2009). It is thus hypothesized that the direct intra- tumal Zn injection could affect the growth of prostate cancer. [...]

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