Drug interactions, liver changes and pancreas
The drug poisoning can be confused with viral hepatitis, with biliary tract obstruction with cirrhosis and hepatoma. The liver can be attacked in various ways: necrosis, hepatitis nonspecific, chronic hepatitis, etc. In the process are involved biotransformation of chemicals and individual susceptibility to them.
Generally not the product that acts directly on the liver, but some of its toxic metabolites. It is difficult to characterize the relationship between the cause and the effect. The hepatotoxic agent may be intrinsic or idiosyncratic type. The intrinsic type hepatotoxin acts quickly (hours or days) and is independent of the body's susceptibility (trichloroethane, solvents with carbon tetrachloride, certain mushrooms and acetaminophen). In type idiosyncratic hepatotoxin acts length (months) and has mixed developments (halothane, isoniazid, phenytoin and Chlorpromazine).
[...] The manifestations of chronic hepatitis are very discrete and often patients are asymptomatic. The main symptom, when present, is fatigue. May occur insomnia and pain in the right upper quadrant. In advanced stages there may be nausea, loss of appetite and weight loss. Most of the time the diagnosis is made through routine blood tests. The elevation of transaminases is the main laboratory characteristic of chronic hepatitis. Bilirubin and proteins in general are normal. There is often thrombocytopenia when the disease is progressing to cirrhosis. [...]
[...] Reach of the population each year and can be acute or chronic. The viral infection is usually self-limiting: disappear spontaneously without causing liver damage. Sometimes, however, the infection becomes persistent generating a process that cronifica, progressing to chronic hepatitis. Some parasites can lead to situations similar to hepatitis (schistosomiasis, malaria and amebiasis). Viral hepatitis are at least five types: D and E. With the exception of Type B (DNA virus), all are RNA viruses. The type A is the most common form of cases, followed by B C and 15%. [...]
[...] Fatigue, sleep disturbances, behavioral changes are examples of liver symptoms. The main diseases affecting the liver in the elderly hepatitis, cirrhosis, tumors and poisoning by drugs. The liver is an organ that often hosts metastases. Liver failure is a situation that must be highlighted, as is the organ failure and can occur in any of the foregoing. The main clinical signs of liver disease are jaundice, abdominal pain, weight loss, fatigue, nausea and vomiting and ascites. Clinical evaluation involves examining the abdomen and laboratory tests. [...]
[...] In this circumstance, the absorption is affected by the interaction between drugs and alters the response to the drug. Alcohol can also interact with prescription drugs. Your continued use of diuretics or cortisone leads to loss of potassium, increasing the risk of cardiac arrhythmias in people who also make use of digitalis. Deficiency of vitamin not uncommon in old age, can facilitate adverse drug reactions. Several tranquilizers, cortisone and allergy increase appetite. Digitalis and anti-inflammatory drugs can lead to loss of appetite. [...]
[...] The histological study by liver biopsy is conclusive: hepatocellular injury, chronic inflammation and fibrosis. Moreover, the histology estadiando evaluates the degree of the injury process. The differential diagnosis include metabolic diseases such as alcoholism and drug intoxication. Chronic hepatitis has no specific treatment. Immunosuppressive drugs may be used. References: Azevedo, JR Staying Young takes time . A Guide to Living Better. Sao Paulo: Saraiva 2 - Cecil Textbook of Medicine. 21th ed. p. 750 Banks PA. ACG Treatment Guideline: Acute Pancreatitis. Am J Gastroenterol 1997; 92 Nov; 92 2032-5. [...]
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