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Neurocognitive Outcomes of Type 1 Diabetes in Children

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  1. Introduction to type 1 diabetes mellitus
    1. What is diabetes Mellitus?
    2. Prevalence and demographics
    3. Neural basis of T1DMa
    4. Treatment
  2. Cognitive outcomes on memory
    1. Neural basis of memory
    2. Cognitive outcome of T1DM on memory
  3. Structural changes in the brain as a result of T1DM: MRI studies
    1. Hippocampus
    2. Effect of T1DM on other brain areas

Type 1 Diabetes Mellitus (T1DM) is a disease caused by the inability of the body to produce insulin. As a result of the human defenses against autoimmune disorders, insulin producing cells in the body are identified as foreign and therefore targeted by immune cells for destruction. Insulin is a hormone produced by the pancreas, which is responsible for regulating blood glucose levels through the regulation of glucose uptake from blood into storage cells. High levels of blood glucose can result in damage of organs such as the kidney, liver, pancreas and brain. The main symptoms of diabetes include weight loss, polynuria and presence of sugar in urine. It is characteristic of T1DM for symptoms to develop quickly especially in young people.

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