Bioactive-rich fractions, Plant bioresources, plant, Bioactives, chronic disease, medicinal plants, phytochemicals, rich fraction
Plant bioresources are relied upon as natural, inexpensive, and sustainable remedies for the management of several chronic diseases worldwide. Plants have historically been consumed for medicinal purposes based on traditional belief, but this trend is currently changing.
The growing interest in the medicinal properties of plant bioresources stems from concerns of side effects and other adverse effects caused by synthetic drugs. This interest has yielded a better understanding of the roles of plant bioactive compounds in health promotion and disease prevention, including the underlying mechanisms involved in such functional effects.
[...] (LDL oxidation is not significantly different between low and high PUFA group). In HUVEC mM TRF treatment decreased TBARS by 73% compared with 50% by same concentration of a-tocopherol. Arachidonic acid-induced oxidative stress (conjugated dienes) was reduced to a similar level by 10 mM TRF or 25 mM a-tocopherol. TRF is a more potent antioxidant than a-tocopherol (in vitro) TRF and a-tocopherol were metabolized differently. Tocopherol was the major component detected in plasma in both cases, and it peaked at 6 h ( 13.46 1.68 mg/mL) and at 8 h ( 24.3 5.22 mg/mL) following TRF and a-tocopherol supplementation, respectively. [...]
[...] DOI: 10.3109 / Bioactive-rich fractions? 5 Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Kungliga Tekniska Hogskolan on 03/06/15 For personal use only M. U. Imam et al. Through in vitro experimentation, Al-Naqeeb and Ismail (2009) have demonstrated the effects of 2 ppm TQ against 80 ppm of a thymoquinone-rich fraction (TQRF containing 2 ppm TQ) on the expression of cholesterol-related genes (APO A1 and APO B100) in HEPG2 cells. The results indicated that the TQRF is able to favorably regulate cholesterol metabolism through upregulation of the APO A1 gene and downregulation of the APO B100 gene to a significantly greater degree than the same concentration of TQ present in the TQRF when used alone. [...]
[...] Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of a-tocopherol. Am J Clin Nutr 835–42. Grace, MH, Ribnicky DM, Kuhn et al. (2009). Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 406–15. Crit Rev Biotechnol, Early Online: Gurib-Fakim A. (2006). Medicinal plants; traditions of yesterday and drugs for tomorrow. Mol Asp Med 1–93. Ha TY, Han Kim SR, et al. (2005). Bioactive components in rice bran oil improve lipid profiles in rats fed a high-cholesterol diet. [...]
[...] Protective effect of 8-week feeding diet supplemented with a-tocopherol or TRF (300 mg/kg food) on aspirin-induced gastric lesions in Sprague–Dawley rats were evaluated. Effects of a-tocopherol and TRF on lipid peroxidation of LDL and HUVEC was evaluated. Samples: Blood obtained from subjects involved in various human dietary feeding trials (only baseline blood samples were used). Subjects consuming a high en) or low PUFA diets en from PUFA) for 6 weeks. Study design Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Kungliga Tekniska Hogskolan on 03/06/15 For personal use only. Bioactive-rich fractions? [...]
[...] Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in Hepg2 cells. J Food Lipids 245–58. Al-Naqeep Ismail Allaudin Z. (2009a). Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. J Nutrigenet Nutrigenomics 163–72. Al-Naqeep Ismail Yazan LS. (2009b). Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression. J Funct Foods 298–303. [...]
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