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The effect of surface functionalisation of zinc doped silica nanoparticles on cellular uptake

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  1. Nanoparticles in cancer treatment applications
  2. SiO2 (silica) nanoparticles and ZnO (zinc oxide) nanoparticles
  3. Properties and Mechanisms of Zinc and its Use in treatment of Cancer
  4. Cellular Uptake of Nanoparticles
  5. Importance of surface modification of nanoparticles on cellular uptake
  6. Liposome (Giant Unilamellar Vesicles) synthesis
  7. Experimental techniques to be used in this project
  8. Summary of literature review

Nanoparticles are described as particles that have less than 100 nanometre (nm) in a dimension (Khan and Arif, 2012, p. 85). Zinc (Zn) is one of the elements that has been known for its anti-cancer properties (Kim et al., 2013). On the other hand, silica nanoparticle (SiO2 NP) is one of the nanomaterial with a huge application particularly when it comes to the project of Nanomedicine (Sahu and Casciano, 2009, p. 125). As such, this project aims to investigate how the functionalizing of SiO2 NPs doped with Zn could affect its cellular uptake.
To learn more about the research topic, this project aims to see how the surface charge of the SiO2 NPs doped with Zn has an effect on cellular uptake. This project will also seek to determine whether or not surface functionalisation of SiO2 NPs doped with Zn could create significant changes within the cellular uptake. In the process of conducting a systematic literature review, it is possible for the reader to gain more insight on what has already been known and unknown when it comes to the possible effects of surface functionalisation of Zn SiO2 NPs doped with Zn on the cellular uptake and its potential for cancer therapy.

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