The purpose of this paper is to analyze the human health effect associated with Dicamba residue on asparagus and soybeans in the United States. Generalizations are made in regards to Dicamba consumption and its lack of toxicity toward human health. ADD, ADI, HQ, and LADD calculations were conducted using asparagus and soybeans as case studies. The researcher concluded that no human health effect is present when consuming the preceding food products. The researcher cannot claim complete accuracy of the calculations included herewith, and although generalizations can be made, using other notable cast studies, results may vary.
Dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a benzoic acid herbicide. It is typically applied to leaves or to the soil to control annual and perennial broadleaf weeds. It is also used to control brush and bracken in pastures (Kegley et al., 2007). Dicamba is an acid which forms salts in aqueous solutions. It was first registered in the United States in 1967 and is widely used in agricultural, industrial, and residential settings.
[...] C = 3 mg/kg IR = 11,000kg .9 BW= 70kg LT = 70 years mg/kg) (11,000kg) ( 0.9 ) / (25,550) = .017 mg/kg/day HQ (asparagus): .012 HQ is less than 1 and is an acceptable level of risk ADD = .006 mg/kg ADI = .5 mg/kg .006 mg/kg / .5 mg/kg = < 1 ADI (soybeans): = 0.5 mg/kg/day ADD (soybeans): .000 mg/kg/day Accordingly, the maximum permitted residue of Dicamba on soybeans is .05ppm. on average Americans consume 660g/year of soybeans C = .05ppm = .005mg/kg BW = 70kg AT = 7days IR = 660g/1000 = 0.66 kg/year = .0127kg/week B = 0.9 (.05mg/kg) (.0127kg) ( 0.9 ) / (70kg) (7days) = .00000116632 LADD (soybeans): .0003 mg/kg/day To calculate the LADD of soybeans, we will be using the IR rate of lettuce of 14,000 kg. [...]
[...] It includes a full description of the calculations that were used in order to gain quantitative as well as qualitative data. It also describes the method in which the data was collected. The data used in calculating the ADI for Dicamba was derived from a study conducted by Industrial BioTest that found a NOEL of 50ppm, when Dicamba was fed to dogs over a two-year span. The research used similar data, for the bioavailability data, which was derived from a lecture handout provided by A. [...]
[...] Validity of the Study In case of validity, the researcher felt like all information used was fairly accurate. Assumptions were made in regards to bioavailability and Ingestion Rate of the asparagus and soybean. The data used, as stated above, was derived from a lecture handout at the Harvard University Extension School. This may or may not have altered any of the data, but it could have made a difference in the overall study. The research constructed was attempted by a novice, and should be seen and reviewed as such. [...]
[...] After reviewing previous case studies, the researcher is comfortable that the results indicated herewith, will mimic previous results, which indicate that Dicamba residue in food do not pose any high level of risk for consumption. Results In this section, the results from the calculations are presented for contextual analysis. In order to analyze the collected data, the researcher used standard ADI, ADD, HQ and LADD equations. Consumption rates were researched for asparagus and soybeans. Conversions were made mathematically in order to satisfy the formulas. [...]
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